Ac-DNLD-CHO

Ac-DNLD-CHO (Ac-Asp-Asn-Leu-Asp-CHO) is a Caspase-3/7 inhibitor (IC50: 9.89, 245 nM respectively; Kiapp: 0.68, 55.7 nM respectively) . Ac-DNLD-CHO can be used for research of caspase-mediated apoptosis diseases, such as neurodegenerative disorders and viral infection diseases[1].

Product Specifications

CAS Number

[775289-20-8]

Product Name Alternative

Ac-Asp-Asn-Leu-Asp-CHO

UNSPSC

12352209

Target

Caspase

Type

Peptides

Related Pathways

Apoptosis

Applications

COVID-19-anti-virus

Field of Research

Infection; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/ac-dnld-cho.html

Solubility

10 mM in DMSO

Smiles

O=C(N[C@@H](CC(C)C)C(N[C@H](C=O)CC(O)=O)=O)[C@H](CC(N)=O)NC([C@@H](NC(C)=O)CC(O)=O)=O

Molecular Formula

C20H31N5O10

Molecular Weight

501.49

References & Citations

[1]Yoshimori A, et al. Structural and functional definition of the specificity of a novel caspase-3 inhibitor, Ac-DNLD-CHO. BMC Pharmacol. 2007 Jun 27;7:8.