Excisanin A

Excisanin A is a potent anticancer agent. Excisanin A inhibits cell proliferation, migration, adhesion and invasion. Excisanin A decreases the expression of MMP-2, MMP-9, p-FAK, p-Src, integrin β1 protein. Excisanin A has the potential for the research of breast cancer[1].

Product Specifications

CAS Number

[78536-37-5]

UNSPSC

12352211

Target

FAK; Integrin; MMP; Src

Type

Natural Products

Related Pathways

Cytoskeleton; Metabolic Enzyme/Protease; Protein Tyrosine Kinase/RTK

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/excisanin-a.html

Solubility

10 mM in DMSO

Smiles

O[C@H]([C@@H]1C2=C)[C@@]([C@@H](C[C@]3([H])C4(C)C)O)(C2=O)[C@](C[C@@H]1O)([H])[C@@]3([C@H](CC4)O)C

Molecular Formula

C20H30O5

Molecular Weight

350.45

References & Citations

[1]Qin J, et al. A diterpenoid compound, excisanin A, inhibits the invasive behavior of breast cancer cells by modulating the integrin β1/FAK/PI3K/AKT/β-catenin signaling. Life Sci. 2013 Nov 4;93 (18-19) :655-63.