Excisanin A
Excisanin A is a potent anticancer agent. Excisanin A inhibits cell proliferation, migration, adhesion and invasion. Excisanin A decreases the expression of MMP-2, MMP-9, p-FAK, p-Src, integrin β1 protein. Excisanin A has the potential for the research of breast cancer[1].
Product Specifications
CAS Number
78536-37-5
UNSPSC
12352211
Target
FAK; Integrin; MMP; Src
Type
Natural Products
Related Pathways
Cytoskeleton; Metabolic Enzyme/Protease; Protein Tyrosine Kinase/RTK
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/excisanin-a.html
Solubility
10 mM in DMSO
Smiles
O[C@H]([C@@H]1C2=C)[C@@]([C@@H](C[C@]3([H])C4(C)C)O)(C2=O)[C@](C[C@@H]1O)([H])[C@@]3([C@H](CC4)O)C
Molecular Formula
C20H30O5
Molecular Weight
350.45
References & Citations
[1]Qin J, et al. A diterpenoid compound, excisanin A, inhibits the invasive behavior of breast cancer cells by modulating the integrin β1/FAK/PI3K/AKT/β-catenin signaling. Life Sci. 2013 Nov 4;93 (18-19) :655-63.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Frequently Asked Questions
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