SB 258741 (hydrochloride)
SB 258741 hydrochloride is a specific 5-HT7 receptor antagonist and can be used for the research of schizophrenia[1].
Product Specifications
UNSPSC
12352005
Target
5-HT Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/sb-258741-hydrochloride.html
Solubility
10 mM in DMSO
Smiles
O=S(N1[C@@H](CCN2CCC(C)CC2)CCC1)(C3=CC=CC(C)=C3)=O.Cl
Molecular Formula
C19H31ClN2O2S
Molecular Weight
386.98
References & Citations
[1]Pouzet B, et al. Effects of the 5-HT (7) receptor antagonist SB-258741 in animal models for schizophrenia. Pharmacol Biochem Behav. 2002 Apr;71 (4) :655-65.|[2]Mahé C, et al. Differential inverse agonist efficacies of SB-258719, SB-258741 and SB-269970 at human recombinant serotonin 5-HT7 receptors. Eur J Pharmacol. 2004 Jul 14;495 (2-3) :97-102.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
5-HT7 Receptor; MUC3
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