2'-Deoxyadenosine-5'-triphosphate-13C10 (dilithium)

2'-Deoxyadenosine-5'-triphosphate-13C10 (dATP-13C10) dilithium is 13C-labeled 2'-Deoxyadenosine-5'-triphosphate (HY-136648) . 2'-Deoxyadenosine-5'-triphosphate (dATP) is a nucleotide used in cells for DNA synthesis (or replication), as a substrate of DNA polymerase.

Product Specifications

Product Name Alternative

DATP-13C10 (dilithium)

UNSPSC

12352005

Target

DNA/RNA Synthesis; Endogenous Metabolite; Isotope-Labeled Compounds

Type

Isotope-Labeled Compounds

Related Pathways

Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Others

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/2-deoxyadenosine-5-triphosphate-13c10-dilithium.html

Concentration

100 mM in 19.49 μL Tris HCl/H2O buffer pH=7.5

Purity

95.0

Solubility

10 mM in DMSO

Smiles

O=P(O)(O[Li])OP(OP(O[13CH2][13C@H]1O[13C@@H](N2[13C]3=N[13CH]=N[13C](N)=[13C]3N=[13CH]2)[13CH2][13C@@H]1O)(O)=O)(O[Li])=O

Molecular Formula

13C10H14Li2N5O12P3

Molecular Weight

512.97

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]P J Romaniuk, A study of the mechanism of T4 DNA polymerase with diastereomeric phosphorothioate analogues of deoxyadenosine triphosphate. J Biol Chem. 1982 Jul 10;257 (13) :7684-8.