2'-Deoxyadenosine-5'-triphosphate-13C10,15N5 (dilithium)
Product Specifications
UNSPSC Description
2'-Deoxyadenosine-5'-triphosphate-13C10,15N5 (dATP-13C10,15N5) dilithium is 13C and 15N-labeled 2'-Deoxyadenosine-5'-triphosphate (HY-136648). 2'-Deoxyadenosine-5'-triphosphate (dATP) is a nucleotide used in cells for DNA synthesis (or replication), as a substrate of DNA polymerase.
Target Antigen
DNA/RNA Synthesis; Endogenous Metabolite; Isotope-Labeled Compounds
Type
Isotope-Labeled Compounds
Related Pathways
Cell Cycle/DNA Damage;Metabolic Enzyme/Protease;Others
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/2-deoxyadenosine-5-triphosphate-13c10-15n5-dilithium.html
Solubility
10 mM in DMSO
Smiles
O=P(O)(O[Li])OP(OP(O[13CH2][13C@H]1O[13C@@H]([15N]2[13C]3=[15N][13CH]=[15N][13C]([15NH2])=[13C]3[15N]=[13CH]2)[13CH2][13C@@H]1O)(O)=O)(O[Li])=O
Molecular Weight
517.94
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.|[2]P J Romaniuk, A study of the mechanism of T4 DNA polymerase with diastereomeric phosphorothioate analogues of deoxyadenosine triphosphate. J Biol Chem. 1982 Jul 10;257(13):7684-8.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-136648S1/2-Deoxyadenosine-5-triphosphate-13C10-15N5-dilithium-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-136648S1/
Clinical Information
No Development Reported
Curated Selection
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