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(R) -Lansoprazole-d4

(R) -Lansoprazole-d4 is deuterium labeled (R) -Lansoprazole. (R) -Lansoprazole is the R enantiomer of Lansoprazole, Lansoprazole (AG 1749) is an orally active proton pump inhibitor which prevents the stomach from producing acid. Lansoprazole (AG 1749) is a potent brain penetrant neutral sphingomyelinase (N-SMase) inhibitor (exosome inhibitor) [1][2].

Product Specifications

Product Name Alternative

Dexlansoprazole-d4

UNSPSC

12352005

Target

Isotope-Labeled Compounds; Proton Pump

Type

Isotope-Labeled Compounds

Related Pathways

Membrane Transporter/Ion Channel; Others

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Purity

99.13

Solubility

10 mM in DMSO

Smiles

O=[S@@](C1=NC2=C([2H])C([2H])=C([2H])C([2H])=C2N1)CC3=NC=CC(OCC(F)(F)F)=C3C

Molecular Formula

C16H10D4F3N3O2S

Molecular Weight

373.39

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Huarui Zhang, et al. Advances in the discovery of exosome inhibitors in cancer. J Enzyme Inhib Med Chem. 2020 Dec;35 (1) :1322-1330.|[3]Kokufu, T., et al., Effects of lansoprazole on pharmacokinetics and metabolism of theophylline. Eur J Clin Pharmacol, 1995. 48 (5) : p. 391-5.|[4]M Miura, et al. Pharmacokinetic differences between the enantiomers of lansoprazole and its metabolite, 5-hydroxylansoprazole, in relation to CYP2C19 genotypes. Eur J Clin Pharmacol. 2004 Nov;60 (9) :623-8.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C, 3 years (Powder)

Scientific Category

Isotope-Labeled Compounds

Clinical Information

No Development Reported

Frequently Asked Questions

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