KRN5500
Product Specifications
CAS Number
151276-95-8
UNSPSC Description
KRN5500 (NSC 650426), a Spicamycin (HY-127130) derivative and a nucleoside-like antibiotic with anti-tumor activity. KRN5500 also induces apoptosis via the down-regulation of Bcl-2 expression. KRN5500 shows a significant efficacy in the human tumor xenograft model in mice[1][2].
Target Antigen
Antibiotic; Apoptosis; Bcl-2 Family
Type
Reference compound
Related Pathways
Anti-infection;Apoptosis
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/krn5500.html
Solubility
10 mM in DMSO
Smiles
O[C@@H]1[C@H](O)[C@@H](NC(CNC(/C=C/C=C/CCCCCCCCC)=O)=O)[C@]([H])([C@@H](O)CO)O[C@@H]1NC2=NC=NC3=C2NC=N3
Molecular Weight
589.68
References & Citations
[1]Zhang WJ, et al. Spicamycin and KRN5500 induce apoptosis in myeloid and lymphoid cell lines with down-regulation of bcl-2 expression and modulation of promyelocytic leukemia protein. Jpn J Cancer Res. 2000 Jun;91(6):604-11. |[2]Kamishohara M, et al. Antitumor activity of a spicamycin derivative, KRN5500, and its active metabolite in tumor cells. Oncol Res. 1994;6(8):383-90.
Shipping Conditions
Room temperature
Clinical Information
Phase 2
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
MBS1084896-01 0.02 mg (E-Coli)
Recombinant Shewanella piezotolerans UPF0502 protein swp_3027 (swp_3027)
Sign In for Pricing
View Details MBS1084896-02 0.1 mg (E-Coli)
Recombinant Shewanella piezotolerans UPF0502 protein swp_3027 (swp_3027)
Sign In for Pricing
View Details MBS1084896-03 0.02 mg (Yeast)
Recombinant Shewanella piezotolerans UPF0502 protein swp_3027 (swp_3027)
Sign In for Pricing
View Details MBS1084896-04 0.1 mg (Yeast)
Recombinant Shewanella piezotolerans UPF0502 protein swp_3027 (swp_3027)
Sign In for Pricing
View Details