BCR-ABL-IN-3

BCR-ABL-IN-3 is a potent and irreversible Bcr-Abl inhibitor with an IC50 of ≤100 nM for Ba/F3Bcr-AblT3151. BCR-ABL-IN-3 has anti-cancer activity[1].

Product Specifications

CAS Number

[2240191-12-0]

UNSPSC

12352005

Target

Bcr-Abl

Type

Reference compound

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/bcr-abl-in-3.html

Solubility

10 mM in DMSO

Smiles

O=C(C1=CC(C2=CSN=C2)=C(N3C[C@H](O)CC3)N=C1)NC4=CC=C(OC(F)(Cl)F)C=C4

Molecular Formula

C20H17ClF2N4O3S

Molecular Weight

466.89

References & Citations

[1]Hanyi Wang, et al. (hetero) arylamide compound for inhibiting protein kinase activity. WO2018133826A1.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

Bcr-Abl

Curated Selection

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