KU-0058948 (hydrochloride)

KU-0058948 hydrochloride is a specific and potent PARP1 inhibitor with an IC50 of 3.4 nM. KU-0058948 hydrochloride induces cell cycle arrest and apoptosis of primary myeloid leukemic cells and myeloid leukemic cell lines[1][2].

Product Specifications

CAS Number

[2108829-86-1]

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Apoptosis; PARP

Type

Reference compound

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ku-0058948-hydrochloride.html

Solubility

10 mM in DMSO

Smiles

O=C1NN=C(CC2=CC=C(F)C(C(N3CCNCCC3)=O)=C2)C4=C1C=CC=C4.[H]Cl

Molecular Formula

C21H22ClFN4O2

Molecular Weight

416.88

Precautions

P261-P280-P302+P352

References & Citations

[1]Hannah Farmer, et al. Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy. Nature. 2005 Apr 14;434 (7035) :917-21. |[2]Gaymes TJ, et al. Inhibitors of poly ADP-ribose polymerase (PARP) induce apoptosis of myeloid leukemic cells: potential for therapy of myeloid leukemia and myelodysplastic syndromes. Haematologica. 2009 May;94 (5) :638-46.