Chrysamine G

Chrysamine G, a carboxylic acid analogue of Congo Red, can be used as a probe of amyloid deposition in Alzheimer's disease. Chrysamine G also can inhibit Aβ-induced toxicity in PC12 cells[1][2].

Product Specifications

CAS Number

[6472-91-9]

UNSPSC

12352005

Target

Amyloid-β

Type

Reference compound

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/chrysamine-g.html

Solubility

10 mM in DMSO

Smiles

O=C(O[Na])C1=C(O)C=CC(/N=N/C2=CC=C(C3=CC=C(/N=N/C4=CC(C(O[Na])=O)=C(O)C=C4)C=C3)C=C2)=C1

Molecular Formula

C26H16N4Na2O6

Molecular Weight

526.41

References & Citations

[1]Klunk WE, et, al. Chrysamine-G binding to Alzheimer and control brain: autopsy study of a new amyloid probe. Neurobiol Aging. Jul-Aug 1995;16 (4) :541-8.|[2]Klunk WE, et, al. Chrysamine-G, a lipophilic analogue of Congo red, inhibits A beta-induced toxicity in PC12 cells. Life Sci. 1998;63 (20) :1807-14.