Bongkrekic acid-13C28

Bongkrekic acid-13C28 is the 13C labeled Bongkrekic acid (HY-136406) . Bongkrekic acid is a mitochondrial toxin secreted by the bacteria Pseudomonas cocovenenans. Bongkrekic acid specific ligand for mitochondrial adenine nucleotide translocase (ANT) rather than the electron transport chain. Bongkrekic acid has to cross the mitochondrial inner membrane to produce its inhibitory effect on ADP/ATP transport[1][2].

Product Specifications

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

ATP Synthase; Isotope-Labeled Compounds

Type

Isotope-Labeled Compounds

Related Pathways

Membrane Transporter/Ion Channel; Others

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/bongkrekic-acid-13c28.html

Concentration

9.72 μM * 1.2 mL in Acetonitrile

Purity

98.0

Solubility

DMSO : 100 mg/mL (ultrasonic; warming)

Smiles

O[13C]([13CH2][13C](/[13CH]=[13CH]/[13C@@H]([13CH3])[13CH2]/[13CH]=[13CH]/[13CH2][13CH2]/[13CH]=[13CH]/[13CH]=[13CH][13CH2][13C@@H](O[13CH3])/[13C]([13CH3])=[13CH]\[13CH]=[13C]([13CH3])\[13C](O)=O)=[13CH]/[13C](O)=O)=O

Molecular Formula

13C28H38O7

Molecular Weight

514.39

Precautions

H302, H315, H319, H335

References & Citations

[1]Mehruba Anwar, et al. Bongkrekic Acid-a Review of a Lesser-Known Mitochondrial Toxin. J Med Toxicol. 2017 Jun;13 (2) :173-179.|[2]C Dahout-Gonzalez, et al. Molecular, functional, and pathological aspects of the mitochondrial ADP/ATP carrier. Physiology (Bethesda) . 2006 Aug:21:242-9.