IKK-IN-4

IKK-IN-4 is a potent and selective IkappaB kinase 2 (IKKβ orIKK2) inhibitor, with IC50s of 45 and 650 nM for IKKβ and IKKα, respectively[1].

Product Specifications

CAS Number

[615529-94-7]

UNSPSC

12352005

Target

IKK

Type

Reference compound

Related Pathways

NF-κB

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/ikk-in-4.html

Solubility

10 mM in DMSO

Smiles

CC1=CN=C2C(NC)=NC(C=C(C3=CC=CC(CCN)=C3)S4)=C4N21

Molecular Formula

C18H19N5S

Molecular Weight

337.44

References & Citations

[1]Belema M, et al. Synthesis and structure-activity relationship of imidazo (1,2-a) thieno (3,2-e) pyrazines as IKK-beta inhibitors. Bioorg Med Chem Lett. 2007;17 (15) :4284‐4289.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Curated Selection

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