3α-Hydroxy pravastatin (sodium)

3α-Hydroxy pravastatin sodium is the major metabolite of Pravastatin. Pravastatin is a competitive HMG-CoA reductase inhibitor[1][2].

Product Specifications

CAS Number

[81093-43-8]

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

Drug Metabolite; HMG-CoA Reductase (HMGCR)

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/3α-hydroxy-pravastatin-sodium.html

Purity

99.35

Solubility

10 mM in DMSO

Smiles

O[C@@H](C[C@@H](O)CC(O[Na])=O)CC[C@@H]([C@H]1C)[C@]([C@H]2OC([C@@H](C)CC)=O)([H])C(C=CC2)=C[C@H]1O

Molecular Formula

C23H35NaO7

Molecular Weight

446.51

Precautions

H302, H315, H319, H335

References & Citations

[1]Zhang X, Vernikovskaya DI, Wang X, et al. Quantitative determination of pravastatin and its metabolite 3α-hydroxy pravastatin in plasma and urine of pregnant patients by LC-MS/MS. Biomed Chromatogr. 2016;30 (4) :548‐554.|[2]Shiomi M, et al. Pravastatin sodium, a competitive inhibitor of hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase, decreases the cholesterol content of newly secreted very-low-density lipoprotein in Watanabe heritable hyperlipidemic rabbits. Metabolism. 1994;43 (5) :559‐564.