Phenylacetic acid mustard

Phenylacetic acid mustard is the major metabolite of the cancer chemotherapeutic agent Chlorambucil (HY-13593) . Chlorambucil is an alkylating agent with antitumor activity[1].

Product Specifications

CAS Number

[10477-72-2]

UNSPSC

12352005

Hazard Statement

H301-H311-H331-H341

Target

DNA Alkylator/Crosslinker

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/phenylacetic-acid-mustard.html

Solubility

10 mM in DMSO

Smiles

O=C(O)CC1=CC=C(N(CCCl)CCCl)C=C1

Molecular Formula

C12H15Cl2NO2

Molecular Weight

276.16

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P361-P403+P233-P405-P501

References & Citations

[1]Toni Pettersson-Fernholm, et al. Reactions of 4-bis (2-chloroethyl) aminophenylacetic acid (phenylacetic acid mustard) in physiological solutions.|[2]F Y Lee, et al. Pharmacokinetic basis for the comparative antitumour activity and toxicity of chlorambucil, phenylacetic acid mustard and, -difluorochlorambucil (CB 7103) in mice.