Etoposide phosphate (disodium)

Etoposide phosphate disodium (BMY-40481 disodium) is a potent anti-cancer chemotherapy agent and a selective topoisomerase II inhibitor to prevent re-ligation of DNA strands. Etoposide phosphate disodium is the phosphate ester proagent of etoposide and is considered as active equivalent to Etoposide. Etoposide phosphate disodium induces cell cycle arrest, apoptosis, and autophagy.

Product Specifications

CAS Number

[122405-33-8]

Product Name Alternative

BMY-40481 (disodium)

UNSPSC

12352005

Target

Apoptosis; Autophagy; Topoisomerase

Type

Reference compound

Related Pathways

Apoptosis; Autophagy; Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/etoposide-phosphate-disodium.html

Solubility

10 mM in DMSO

Smiles

O=C1OC[C@]2([H])[C@H](O[C@H]3[C@@H]([C@H]([C@@H]([C@@H](CO4)O3)O[C@@H]4C)O)O)C5=C(C=C6OCOC6=C5)[C@@H](C7=CC(OC)=C(OP(O[Na])(O[Na])=O)C(OC)=C7)[C@]21[H]

Molecular Formula

C29H31Na2O16P

Molecular Weight

712.50

References & Citations

[1]Witterland AH, et al. Etoposide phosphate, the water soluble prodrug of etoposide. Pharm World Sci. 1996 Oct;18 (5) :163-70.|[2]Cui D, et al. FBXW7 Confers Radiation Survival by Targeting p53 for Degradation.Cell Rep. 2020 Jan 14;30 (2) :497-509.e4.|[3]Bregman CL, et al. Etoposide- and BMY-40481-induced sensory neuropathy in mice.Toxicol Pathol. 1994 Sep-Oct;22 (5) :528-35.|[4]SUMMARY OF PRODUCT CHARACTERISTICS