DMNPE-4 AM-caged-calcium
DMNPE-4 AM-caged-calcium, photolabile analogues of EGTA, is an extremely effective Ca2+ selective cage, with a Kd for Ca2+ of 48 nM and 19 nM at pH 7.2 and pH 7.4, respectively. DMNPE-4 AM-caged-calcium has a lower affinity for Ca2+ (Kd=~2 nM) after photolysis[1][2].
Product Specifications
CAS Number
2253744-58-8
UNSPSC
12352005
Target
Calcium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/dmnpe-4-am-caged-calcium.html
Solubility
10 mM in DMSO
Smiles
O=C(CN(CCOCCOC(C1=C([N+]([O-])=O)C=C(OC)C(OC)=C1)CN(CC(OCOC(C)=O)=O)CC(OCOC(C)=O)=O)CC(OCOC(C)=O)=O)OCOC(C)=O
Molecular Formula
C34H47N3O22
Molecular Weight
849.74
References & Citations
[1]Ellis-Davies GCR, et, al. Tuning caged calcium: photolabile analogues of EGTA with improved optical and chelation properties. Cell Calcium. 2006 Jan;39 (1) :75-83.|[2]DelPrincipe F, et, al. Two-photon and UV-laser flash photolysis of the Ca2+ cage, dimethoxynitrophenyl-EGTA-4. Cell Calcium. 1999 Jan;25 (1) :85-91.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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