BMS-687453

BMS-687453 is a potent and selective PPARα agonist, with an EC50 and IC50 of 10 nM and 260 nM for human PPARα and 4100 nM and >15000 nM for PPARγ in PPAR-GAL4 transactivation assays.

Product Specifications

CAS Number

[1000998-59-3]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

PPAR

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Applications

COVID-19-anti-virus

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/BMS-687453.html

Purity

99.31

Solubility

DMSO : ≥ 100 mg/mL

Smiles

ClC(C=C1)=CC=C1C2=NC(COC3=CC=CC(CN(C(OC)=O)CC(O)=O)=C3)=C(C)O2

Molecular Formula

C22H21ClN2O6

Molecular Weight

444.86

Precautions

H302, H315, H319, H335

References & Citations

[1]Li J, et al. Discovery of an oxybenzylglycine based peroxisome proliferator activated receptor alpha selective agonist 2- ((3- ((2- (4-chlorophenyl) -5-methyloxazol-4-yl) methoxy) benzyl) (methoxycarbonyl) amino) acetic acid (BMS-687453) . J Med Chem. 2010 Apr 8;53 (7) :2854-64.|[2]Mukherjee R, et al. Novel peroxisome proliferator-activated receptor alpha agonists lower low-density lipoprotein and triglycerides, raise high-density lipoprotein, and synergistically increase cholesterol excretion with a liver X receptor agonist. J Pharmacol Exp Ther. 2008 Dec;327 (3) :716-26.|[3]Vassallo JD, et al. Biomarkers of drug-induced skeletal muscle injury in the rat: troponin I and myoglobin. Toxicol Sci. 2009 Oct;111 (2) :402-12.