Spisulosine-d3

Spisulosine-d3 (ES-285-d3) is deuterium labeled Spisulosine (HY-13626) . Spisulosine is an antiproliferative (antitumoral) compound of marine origin. Spisulosine inhibits the growth of the prostate PC-3 and LNCaP cells through intracellular ceramide accumulation and PKCζ activation. Spisulosine induces apoptosis in PC-3 and LNCaP cells[1].

Product Specifications

CAS Number

[1246298-31-6]

Product Name Alternative

ES-285-d3

UNSPSC

12352211

Target

Apoptosis; Isotope-Labeled Compounds; PKC

Type

Isotope-Labeled Compounds

Related Pathways

Apoptosis; Epigenetics; Others; TGF-beta/Smad

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Purity

99.0

Solubility

10 mM in DMSO

Smiles

[2H]C([2H])([2H])[C@H](N)[C@H](O)CCCCCCCCCCCCCCC

Molecular Formula

C18H36D3NO

Molecular Weight

288.53

References & Citations

[1]Ana M Sánchez, et al. Spisulosine (ES-285) induces prostate tumor PC-3 and LNCaP cell death by de novo synthesis of ceramide and PKCzeta activation. Eur J Pharmacol. 2008 Apr 28;584 (2-3) :237-45. |[2]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-223.