Spisulosine-d3
Product Specifications
UNSPSC Description
Spisulosine-d3 is deuterium labeled Spisulosine. Spisulosine (ES-285) is an antiproliferative (antitumoral) compound of marine origin. Spisulosine inhibits the growth of the prostate PC-3 and LNCaP cells through intracellular ceramide accumulation and PKC
Target Antigen
Isotope-Labeled Compounds; PKC
Type
Isotope-Labeled Compounds
Related Pathways
Epigenetics;Others;TGF-beta/Smad
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Purity
99.0
Solubility
10 mM in DMSO
Smiles
[2H]C([2H])([2H])[C@H](N)[C@H](O)CCCCCCCCCCCCCCC
Molecular Weight
288.53
References & Citations
[1]Ana M Sánchez, et al. Spisulosine (ES-285) induces prostate tumor PC-3 and LNCaP cell death by de novo synthesis of ceramide and PKCzeta activation. Eur J Pharmacol. 2008 Apr 28;584(2-3):237-45. |[2]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-223.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Clinical Information
No Development Reported
CAS Number
1246298-31-6
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