Spisulosine-d3
Spisulosine-d3 (ES-285-d3) is deuterium labeled Spisulosine (HY-13626) . Spisulosine is an antiproliferative (antitumoral) compound of marine origin. Spisulosine inhibits the growth of the prostate PC-3 and LNCaP cells through intracellular ceramide accumulation and PKCζ activation. Spisulosine induces apoptosis in PC-3 and LNCaP cells[1].
Product Specifications
CAS Number
[1246298-31-6]
Product Name Alternative
ES-285-d3
UNSPSC
12352211
Target
Apoptosis; Isotope-Labeled Compounds; PKC
Type
Isotope-Labeled Compounds
Related Pathways
Apoptosis; Epigenetics; Others; TGF-beta/Smad
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Purity
99.0
Solubility
10 mM in DMSO
Smiles
[2H]C([2H])([2H])[C@H](N)[C@H](O)CCCCCCCCCCCCCCC
Molecular Formula
C18H36D3NO
Molecular Weight
288.53
References & Citations
[1]Ana M Sánchez, et al. Spisulosine (ES-285) induces prostate tumor PC-3 and LNCaP cell death by de novo synthesis of ceramide and PKCzeta activation. Eur J Pharmacol. 2008 Apr 28;584 (2-3) :237-45. |[2]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-223.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
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