Spisulosine

Spisulosine (ES-285) is an antiproliferative (antitumoral) compound of marine origin. Spisulosine inhibits the growth of the prostate PC-3 and LNCaP cells through intracellular ceramide accumulation and PKCζ activation. Spisulosine induces apoptosis in PC-3 and LNCaP cells[1].

Product Specifications

CAS Number

[196497-48-0]

Product Name Alternative

ES-285

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; PKC

Type

Natural Products

Related Pathways

Apoptosis; Epigenetics; TGF-beta/Smad

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/spisulosine.html

Purity

99.00

Solubility

DMSO : 2 mg/mL (ultrasonic; warming)

Smiles

C[C@H](N)[C@H](O)CCCCCCCCCCCCCCC

Molecular Formula

C18H39NO

Molecular Weight

285.51

Precautions

H302, H315, H319, H335

References & Citations

[1]Ana M Sánchez, et al. Spisulosine (ES-285) induces prostate tumor PC-3 and LNCaP cell death by de novo synthesis of ceramide and PKCzeta activation. Eur J Pharmacol. 2008 Apr 28;584 (2-3) :237-45.