(S, R, S) -AHPC-C2-NH2 (dihydrochloride)
(S, R, S) -AHPC-C2-NH2 dihydrochloride incorporates a VHL ligand for the E3 ubiquitin ligase, and a PROTAC linker. (S, R, S) -AHPC-OH can be used in the synthesis of a series of PROTACs[1].
Product Specifications
CAS Number
[2341796-73-2]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
E3 Ligase Ligand-Linker Conjugates
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/s-r-s-ahpc-c2-nh2-dihydrochloride.html
Purity
98.63
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
O=C(N(C[C@@H]1O)[C@@H](C1)C(NCC2=CC=C(C(SC=N3)=C3C)C=C2)=O)[C@H](C(C)(C)C)NC(CCN)=O.Cl.Cl
Molecular Formula
C25H37Cl2N5O4S
Molecular Weight
574.56
Precautions
H302, H315, H319, H335
References & Citations
[1]Jing Liu, et al. Tropomyosin receptor kinase (trk) degradation compounds and methods of use. WO2020038415A1.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Von Hippel-Lindau (VHL)
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