Amphotericin X1

Amphotericin X1 is an 13-O-methyl derivative of Amphotericin B with good antifungal activity. Amphotericin X1 inhibits Candida albicans 33/079, C.parapsilosis 937A, Cryptococcus neoformans 451, Aspergillus niger 57A and A.fumigatus with MIC values of 1 μg/mL, 8 μg/mL, 1 μg/mL, 2 μg/mL and 2 μg/mL, respectively[1].

Product Specifications

CAS Number

[136135-57-4]

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Fungal

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/amphotericin-x1.html

Solubility

10 mM in DMSO

Smiles

CO[C@](C[C@@H]1O)(C[C@H](C[C@H]([C@@H](CC[C@H](C[C@H](CC(O[C@H]([C@@H]([C@@H]2O)C)C)=O)O)O)O)O)O)O[C@](C[C@H](/C=C/C=C/C=C/C=C/C=C/C=C/C=C/[C@@H]2C)O[C@@](O[C@@H]3C)([H])[C@H]([C@H]([C@@H]3O)N)O)([H])[C@@H]1C(O)=O

Molecular Formula

C48H75NO17

Molecular Weight

938.11

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Taylor AW, et al. Synthesis and antifungal selectivity of new derivatives of amphotericin B modified at the C-13 position. J Antibiot (Tokyo) . 1993 Mar;46 (3) :486-93.