N, N-Bis (PEG2-alkyne) -N-amido-PEG2-thiol
N, N-Bis (PEG2-alkyne) -N-amido-PEG2-thiol is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) [1]. N, N-Bis (PEG2-alkyne) -N-amido-PEG2-thiol is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Product Specifications
UNSPSC
12352203
Target
ADC Linker
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/n-n-bis-peg2-alkyne-n-amido-peg2-thiol.html
Solubility
10 mM in DMSO
Smiles
O=C(CCOCCOCCS)N(CCOCCOCC#C)CCOCCOCC#C
Molecular Formula
C21H35NO7S
Molecular Weight
445.57
References & Citations
[1]Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16 (5) :315-337.
Shipping Conditions
Room temperature
Scientific Category
ADC Related
Clinical Information
No Development Reported
Isoform
Cleavable Linker
Explore Other Products
Browse additional items from our catalog
Recombinant Campylobacter Concisus ndk Protein (aa 1-137)
Influenza A H7N9 (A/Pigeon/Shanghai/S1069/2013) Hemagglutinin / HA Protein (ECD, His Tag)
Human Serine incorporator 3, SERINC3 ELISA Kit
Human Serine incorporator 3, SERINC3 ELISA Kit
Human Serine incorporator 3, SERINC3 ELISA Kit