N, N-Bis (PEG2-alkyne) -N-amido-PEG2-thiol
N, N-Bis (PEG2-alkyne) -N-amido-PEG2-thiol is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) [1]. N, N-Bis (PEG2-alkyne) -N-amido-PEG2-thiol is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Product Specifications
UNSPSC
12352203
Target
ADC Linker
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/n-n-bis-peg2-alkyne-n-amido-peg2-thiol.html
Solubility
10 mM in DMSO
Smiles
O=C(CCOCCOCCS)N(CCOCCOCC#C)CCOCCOCC#C
Molecular Formula
C21H35NO7S
Molecular Weight
445.57
References & Citations
[1]Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16 (5) :315-337.
Shipping Conditions
Room temperature
Scientific Category
ADC Related
Clinical Information
No Development Reported
Isoform
Cleavable Linker
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