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Tubulin inhibitor 8

Selected Variant

HY-136123

Size: 1 mg

Tubulin inhibitor 8 (Compound 33b) is a tubulin inhibitor and a potent inhibitor of multiple cancer cell lines. Tubulin inhibitor 8 inhibits tubulin polymerization with an IC50 of 0.73 μM. Tubulin inhibitor 8 inhibits K562 cell growth with an IC50 of 14 nM[1].

Product Specifications

CAS Number

1309925-39-0

UNSPSC

12352005

Hazard Statement

H315-H319-H320

Target

Microtubule/Tubulin

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Cytoskeleton

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/tubulin-inhibitor-8.html

Solubility

10 mM in DMSO

Smiles

N#CC1=CC=C2N(C(C3=CC=C(OC)C=C3)=O)C4=C(C=CC=C4)OC2=C1

Molecular Formula

C21H14N2O3

Molecular Weight

342.35

Precautions

P264-P280-P302+P352-P305+P351+P338-P362

References & Citations

[1]Prinz H, et al. N-benzoylated phenoxazines and phenothiazines: synthesis, antiproliferative activity, and inhibition of tubulin polymerization. J Med Chem. 2011 Jun 23;54 (12) :4247-63.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Price

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