TCO-PEG1-Val-Cit-PABC-PNP
TCO-PEG1-Val-Cit-PABC-PNP is a cleavable 1 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . TCO-PEG1-Val-Cit-PABC-PNP is a click chemistry reagent, which contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups[1].
Product Specifications
UNSPSC
12352203
Hazard Statement
H302-H315-H319-H335
Target
ADC Linker
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/tco-peg1-val-cit-pabc-pnp.html
Solubility
10 mM in DMSO
Smiles
O=C(OC1/C=C/CCCCC1)NCCOCCC(N[C@H](C(N[C@H](C(NC2=CC=C(C=C2)COC(OC3=CC=C([N+]([O-])=O)C=C3)=O)=O)CCCNC(N)=O)=O)C(C)C)=O
Molecular Formula
C39H53N7O12
Molecular Weight
811.88
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16 (5) :315-337.
Shipping Conditions
Room temperature
Scientific Category
ADC Related
Clinical Information
No Development Reported
Isoform
Cleavable Linker; Protease Cleavable Linker
Explore Other Products
Browse additional items from our catalog
Tissue, Genomic DNA, Human Disease (Adult), Alzheimer's Disease, Brain, Corpus Callosum, BioGenomicsTM
ANXA3, NT (Annexin A3, Annexin-3, Annexin III, Lipocortin III, Placental Anticoagulant Protein III, PAP-III, 35-alpha Calcimedin, Inositol 1,2-cyclic Phosphate 2-phosphohydrolase, ANX3) (AP) discontinued