Maleimide-PEG2-hydrazide (TFA)
Maleimide-PEG2-hydrazide (TFA) is a cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) [1].
Product Specifications
CAS Number
[2512213-64-6]
UNSPSC
12352203
Hazard Statement
H302, H315, H319, H335
Target
ADC Linker
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/maleimide-peg2-hydrazide-tfa.html
Purity
80.0
Solubility
10 mM in DMSO
Smiles
NNC(CCOCCOCCNC(CCN1C(C=CC1=O)=O)=O)=O.O=C(O)C(F)(F)F
Molecular Formula
C16H23F3N4O8
Molecular Weight
456.37
Precautions
H302, H315, H319, H335
References & Citations
[1]Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16 (5) :315-337.
Shipping Conditions
Dry Ice
Storage Conditions
-80°C, sealed storage, away from moisture and light
Scientific Category
ADC Related
Clinical Information
No Development Reported
Isoform
Acid Cleavable Linker; Cleavable Linker
Available Sizes
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