Androsta-1,4,6-triene-3,17-dione

Androsta-1,4,6-triene-3,17-dione is a lipophilic and specific aromatase inhibitor with a Ki of 0.18 μM. Androsta-1,4,6-triene-3,17-dione inhibits estrogen biosynthesis and shows antifertility effects. Androsta-1,4,6-triene-3,17-dione induces impairment of spatial memory[1][2].

Product Specifications

CAS Number

[633-35-2]

UNSPSC

12352211

Target

Cytochrome P450

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Endocrinology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/androsta-1-4-6-triene-3-17-dione.html

Solubility

10 mM in DMSO

Smiles

C[C@]1([C@](CC2)([H])[C@]3([H])C=CC4=CC(C=C[C@]4(C)[C@@]3([H])CC1)=O)C2=O

Molecular Formula

C19H22O2

Molecular Weight

282.38

References & Citations

[1]Covey DF, et al. Enzyme-generated intermediates derived from 4-androstene-3,6,17-trione and 1,4,6-androstatriene-3,17-dione cause a time-dependent decrease in human placental aromatase activity. Endocrinology. 1981 Apr;108 (4) :1597-9.|[2]Brodie AM, et al. Antifertility effects of an aromatase inhibitor, 1,4,6-androstatriene-3, 17-dione. Endocrinology. 1979 Jan;104 (1) :118-21.