Aminooxy-PEG2-bis-PEG3-BCN
Product Specifications
UNSPSC Description
Aminooxy-PEG2-bis-PEG3-BCN is a cleavable 5 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Aminooxy-PEG2-bis-PEG3-BCN is a click chemistry reagent, it contains a BCN group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
Target Antigen
ADC Linker
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/aminooxy-peg2-bis-peg3-dbco.html
Solubility
10 mM in DMSO
Smiles
O=C(NCCOCCOCCOCCNC(OC[C@@H]1[C@]2(CCC#CCC[C@]21[H])[H])=O)CCOCC(NC(CCOCCOCCON)=O)COCCC(NCCOCCOCCOCCNC(OC[C@@H]3[C@]4(CCC#CCC[C@]43[H])[H])=O)=O
Molecular Weight
1111.32
References & Citations
[1]Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-136089/Aminooxy-PEG2-bis-PEG3-BCN-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-136089/
Clinical Information
No Development Reported
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