Amino-bis-PEG3-BCN
Amino-bis-PEG3-BCN is a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) [1]. Amino-bis-PEG3-BCN is a click chemistry reagent, it contains a BCN group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
Product Specifications
UNSPSC
12352203
Hazard Statement
H302, H315, H319, H335
Target
ADC Linker
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/amino-bis-peg3-bcn.html
Purity
95.05
Solubility
10 mM in DMSO
Smiles
O=C(NCCOCCOCCOCCNC(OC[C@@H]1[C@]2(CCC#CCC[C@]21[H])[H])=O)CCOCC(N)COCCC(NCCOCCOCCOCCNC(OC[C@@H]3[C@]4(CCC#CCC[C@]43[H])[H])=O)=O
Molecular Formula
C47H77N5O14
Molecular Weight
936.14
Precautions
H302, H315, H319, H335
References & Citations
[1]Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16 (5) :315-337.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture and light)
Scientific Category
ADC Related
Clinical Information
No Development Reported
Isoform
Cleavable Linker
Available Sizes
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
APC-Linked Polyclonal Antibody to Receptor Tyrosine Kinase Like Orphan Receptor 1 (ROR1)
APC-Linked Polyclonal Antibody to Receptor Tyrosine Kinase Like Orphan Receptor 1 (ROR1)
APC-Linked Polyclonal Antibody to Receptor Tyrosine Kinase Like Orphan Receptor 1 (ROR1)
APC-Linked Polyclonal Antibody to Receptor Tyrosine Kinase Like Orphan Receptor 1 (ROR1)