TCO-PEG3-aldehyde
TCO-PEG3-aldehyde is a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) [1]. TCO-PEG3-aldehyde is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
Product Specifications
UNSPSC
12352203
Hazard Statement
H302-H315-H319-H335
Target
ADC Linker
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/tco-peg3-aldehyde.html
Solubility
10 mM in DMSO
Smiles
O=C(NCCOCCOCCOCCNC(C1=CC=C(C([H])=O)C=C1)=O)O[C@H]2CCC/C([H])=C/CC2
Molecular Formula
C25H36N2O7
Molecular Weight
476.56
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16 (5) :315-337.
Shipping Conditions
Room temperature
Scientific Category
ADC Related
Clinical Information
No Development Reported
Isoform
Cleavable Linker
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
P21WAF1 (Tumor Suppressor Protein) (CIP1/2489R), CF405S conjugate, 0.1mg/mL
