Desfluoro-ezetimibe

Desfluoro-ezetimibe is a desfluoro impurity of Ezetimibe. Ezetimibe is a potent, metabolically stable cholesterol absorption inhibitor. Ezetimibe is a Niemann-Pick C1-like1 (NPC1L1) inhibitor, and is a potent Nrf2 activator[1][2].

Product Specifications

CAS Number

[302781-98-2]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Autophagy; Keap1-Nrf2

Type

Reference compound

Related Pathways

Autophagy; NF-κB

Applications

Cancer-programmed cell death

Field of Research

Cancer; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/desfluoro-ezetimibe.html

Purity

99.54

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

O=C1N(C2=CC=CC=C2)[C@H](C3=CC=C(O)C=C3)[C@H]1CC[C@@H](C4=CC=C(F)C=C4)O

Molecular Formula

C24H22FNO3

Molecular Weight

391.43

Precautions

H302, H315, H319, H335

References & Citations

[1]Bellur Atici E, et al. Identification, synthesis and characterization of process related desfluoro impurity of ezetimibe and HPLC method validations. J Pharm Anal. 2015 Dec;5 (6) :356-370.|[2]Lee DH, et al. Ezetimibe, an NPC1L1 inhibitor, is a potent Nrf2 activator that protects mice from diet-induced nonalcoholic steatohepatitis. Free Radic Biol Med. 2016 Sep 12;99:520-532.