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N3-PEG4-amido-Lys (Fmoc) -acid

N3-PEG4-amido-Lys (Fmoc) -acid is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) [1]. N3-PEG4-amido-Lys (Fmoc) -acid is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

Product Specifications

UNSPSC

12352203

Target

ADC Linker

Type

ADC Related

Related Pathways

Antibody-drug Conjugate/ADC Related

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/n3-peg4-amido-lys-fmoc-acid.html

Solubility

10 mM in DMSO

Smiles

OC([C@@H](NC(OCC1C2=C(C3=C1C=CC=C3)C=CC=C2)=O)CCCCNC(CCOCCOCCOCCOCCN=[N+]=[N-])=O)=O

Molecular Formula

C32H43N5O9

Molecular Weight

641.71

References & Citations

[1]Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16 (5) :315-337.

Shipping Conditions

Room temperature

Scientific Category

ADC Related

Clinical Information

No Development Reported

Isoform

Cleavable Linker

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