APN-PEG4-PFP

APN-PEG4-PFP is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. APN-PEG4-PFP is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Product Specifications

UNSPSC

12352005

Target

PROTAC Linkers

Type

Reference compound

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/apn-peg4-pfp.html

Solubility

10 mM in DMSO

Smiles

FC1=C(OC(CCOCCOCCOCCOCCNC(C2=CC=C(C#CC#N)C=C2)=O)=O)C(F)=C(F)C(F)=C1F

Molecular Formula

C27H25F5N2O7

Molecular Weight

584.49

References & Citations

[1]An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562