RIP2 Kinase Inhibitor 4
RIP2 Kinase Inhibitor 4 is a potent and selective RIPK2 PROTAC. RIP2 Kinase Inhibitor 4 effectively degrades RIPK2 (pIC50 of 8) and inhibits the release of related TNF-α[1].
Product Specifications
CAS Number
2126803-41-4
UNSPSC
12352005
Target
PROTACs; RIP kinase
Type
Reference compound
Related Pathways
Apoptosis; PROTAC
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/rip2-kinase-inhibitor-4.html
Solubility
10 mM in DMSO
Smiles
CC1=C(C)NN=C1NC2=NC=NC3=C2C=C(S(C(C)(C)C)(=O)=O)C(OCCCN4CCN(C5=NC=C(C(N[C@@H]6CN(C([C@H](C(C)(C)C)NC([C@H](C)NC)=O)=O)[C@H](C(NC(C(F)=CC=C7)=C7F)=O)C6)=O)N=C5)CC4)=C3
Molecular Formula
C50H66F2N14O7S
Molecular Weight
1045.21
References & Citations
[1]Afjal H Miah, et al. Optimization of a Series of RIPK2 PROTACs. J Med Chem. 2021 Sep 9;64 (17) :12978-13003.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CIAP1; RIPK2
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