DBCO-NHCO-PEG2-CH2COOH
DBCO-NHCO-PEG2-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. DBCO-NHCO-PEG2-CH2COOH is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
Product Specifications
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
PROTAC Linkers
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/dbco-nhco-peg2-ch2cooh.html
Solubility
10 mM in DMSO
Smiles
O=C(N1CC2=C(C#CC3=C1C=CC=C3)C=CC=C2)CCNC(CCOCCOCCC(O)=O)=O
Molecular Formula
C26H28N2O6
Molecular Weight
464.51
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PEG Linkers
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
GTR10322949 96 Well
Guinea Pig Cell cycle checkpoint protein RAD1 (RAD1) ELISA Kit
Sign In for Pricing
View Details HEA97106-01 250 mg
3- (Aminocarbonyl) -1,6-dimethyl-pyridinium iodide
Sign In for Pricing
View Details HEA97106-02 500 mg
3- (Aminocarbonyl) -1,6-dimethyl-pyridinium iodide
Sign In for Pricing
View Details