Synucleozid
Product Specifications
UNSPSC Description
Synucleozid (NSC 377363) is a potent inhibitor of the SNCA?mRNA that encodes α-synuclein protein. Synucleozid selectively?targets the α-synuclein mRNA 5′ UTR at the designed IRE site, decreases the amount of?SNCA mRNA loaded into polysomes and thereby inhibits?SNCA?translation. Synucleozid has the potential for the investigation of Parkinson’s disease[1].
Target Antigen
DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/synucleozid.html
Solubility
10 mM in DMSO
Smiles
N=C(C1=CC2=C(C=C1)C=C(C3=CC=C(NC4=CC=C(C(N)=N)C=C4)C=C3)N2)N
Molecular Weight
368.43
References & Citations
[1]Zhang P, et al. Translation of the intrinsically disordered protein α-synuclein is inhibited by a small molecule targeting its structured mRNA.Proc Natl Acad Sci U S A. 2020 Jan 21;117(3):1457-1467.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-135902/Synucleozid-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-135902/
Clinical Information
No Development Reported
CAS Number
502139-01-7
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