Cefsulodin (sodium hydrate)

Cefsulodin (SCE-129) sodium is a third generation β lactam antibiotic and member of the cephems subgroup of antibiotics. Cefsulodin sodium inhibits cell wall synthesis by competitively inhibiting penicillin binding protein (PBP) cross-linking and transpeptidation of peptidogly. Cefsulodin sodium is a potent tyrosine phosphatase inhibitor against mPTPB, a virulent phosphatase from Mycobacterium tuberculosis, with an IC50 value of 16 μM[1][2][3][4].

Product Specifications

CAS Number

[1426397-23-0]

Product Name Alternative

SCE-129 (sodium hydrate)

UNSPSC

12352005

Hazard Statement

H317-H334

Target

Antibiotic; Bacterial

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/cefsulodin-sodium-hydrate.html

Solubility

10 mM in DMSO

Smiles

[O-]C(C1=C(C[N+]2=CC=C(C(N)=O)C=C2)CS[C@@]([C@@H]3NC([C@@H](C4=CC=CC=C4)S(=O)(O[Na])=O)=O)([H])N1C3=O)=O.[F,Cl,Br,I].O

Molecular Formula

C22H19N4O8S2.Na.XH2O

Molecular Weight

554.53 (Anhydrous)

Precautions

P261-P272-P280-P284-P302+P352-P304+P340-P362+P364-P501

References & Citations

[1]King A, et al. In vitro antibacterial activity and susceptibility of cefsulodin, an antipseudomonal cephalosporin, to beta-lactamases. Antimicrob Agents Chemother. 1980 Feb;17 (2) :165-9.|[2]Gotoh N, et al. Resistance of Pseudomonas aeruginosa to cefsulodin: modification of penicillin-binding protein 3 and mapping of its chromosomal gene. J Antimicrob Chemother. 1990 Apr;25 (4) :513-23.|[3]He R, et al. Cefsulodin Inspired Potent and Selective Inhibitors of mPTPB, a Virulent Phosphatase from Mycobacterium tuberculosis. ACS Med Chem Lett. 2015 Nov 3;6 (12) :1231-5.|[4]Sack K, et al. Renal tolerance of imipenem/cilastatin and other beta-lactam antibiotics in rats. Infection. 1985;13 Suppl 1:S156-60.