TP3011
Product Specifications
UNSPSC Description
TP3011 (CH0793011) is an active metabolite of CH-0793076 and is a potent?topoisomerase I?inhibitor equipotent as SN38[1]. TP3011 is against cancer cell lines growth with IC50s at the range sub-nanomolar in vitro[2].
Target Antigen
Topoisomerase
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/tp3011.html
Solubility
10 mM in DMSO
Smiles
O=C(N1CCCCC)NC2=C3C1=C(CN4C(C(COC([C@@]5(CC)O)=O)=C5C=C46)=O)C6=NC3=CC=C2
Molecular Weight
474.51
References & Citations
[1]Anthoney DA, et al. Phase I study of TP300 in patients with advanced solid tumors with pharmacokinetic, pharmacogenetic and pharmacodynamic analyses.BMC Cancer. 2012 Nov 21;12:536.|[2]Niizuma S, et al. Synthesis of new camptothecin analogs with improved antitumor activities.Bioorg Med Chem Lett. 2009 Apr 1;19(7):2018-21.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-135845/TP3011-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-135845/
Clinical Information
No Development Reported
CAS Number
534605-74-8
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