AHR antagonist 4
AHR antagonist 4 is a 2-heteroaryl-3-oxo-2,3-dihydropyridazine-4-carboxamide compound and a potent aryl hydrocarbon receptor (AHR) antagonist extracted from patent WO2018146010A1, example 293, has an IC50 of 82.2 nM. AHR antagonist 4 has anti-cancer effects[1].
Product Specifications
CAS Number
[2242465-58-1]
UNSPSC
12352005
Target
Aryl Hydrocarbon Receptor
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ahr-antagonist-4.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=CC(C2=CC=C(OC(F)(F)F)C=C2)=NN(C3=CC=CN=C3)C1=O)NC[C@H](O)C(F)(F)F
Molecular Formula
C20H14F6N4O4
Molecular Weight
488.34
References & Citations
[1]Ilona GUTCHER, et al. 2-heteroaryl-3-oxo-2,3-dihydropyridazine-4-carboxamides for the treatment of cancer. WO2018146010A1.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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