XM462
XM462 is a dihydroceramide desaturase inhibitor. XM462 produced a mixed-type inhibition (Ki=2 μM) in vitro. XM462 has dihydroceramide desaturase inhibition both in vitro and in cultured cells with IC50 values of 8.2 and 0.78 μM, respectively. XM462 can be used for the research of tumor[1][2].
Product Specifications
CAS Number
[1045857-53-1]
UNSPSC
12352211
Target
Others
Type
Reference compound
Related Pathways
Others
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/xm462.html
Purity
99.80
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CCCCCCCC(N[C@@H](CO)[C@H](O)CSCCCCCCCCCCCCC)=O
Molecular Formula
C25H51NO3S
Molecular Weight
445.74
References & Citations
[1]Munoz-Olaya JM, et al. Synthesis and biological activity of a novel inhibitor of dihydroceramide desaturase. ChemMedChem. 2008 Jun;3 (6) :946-53.|[2]Camacho L, et al. 3-Deoxy-3,4-dehydro analogs of XM462. Preparation and activity on sphingolipid metabolism and cell fate. Bioorg Med Chem. 2012 May 15;20 (10) :3173-9.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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