XM462

XM462 is a dihydroceramide desaturase inhibitor. XM462 produced a mixed-type inhibition (Ki=2 μM) in vitro. XM462 has dihydroceramide desaturase inhibition both in vitro and in cultured cells with IC50 values of 8.2 and 0.78 μM, respectively. XM462 can be used for the research of tumor[1][2].

Product Specifications

CAS Number

[1045857-53-1]

UNSPSC

12352211

Target

Others

Type

Reference compound

Related Pathways

Others

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/xm462.html

Purity

99.80

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CCCCCCCC(N[C@@H](CO)[C@H](O)CSCCCCCCCCCCCCC)=O

Molecular Formula

C25H51NO3S

Molecular Weight

445.74

References & Citations

[1]Munoz-Olaya JM, et al. Synthesis and biological activity of a novel inhibitor of dihydroceramide desaturase. ChemMedChem. 2008 Jun;3 (6) :946-53.|[2]Camacho L, et al. 3-Deoxy-3,4-dehydro analogs of XM462. Preparation and activity on sphingolipid metabolism and cell fate. Bioorg Med Chem. 2012 May 15;20 (10) :3173-9.