Desethyl chloroquine
Desethyl chloroquine is a major desethyl metabolite of Chloroquine. Chloroquine diphosphate is an inhibitor of autophagy and toll-like receptors (TLRs) . Desethyl chloroquine possesses antiplasmodic activity[1][2].
Product Specifications
CAS Number
1476-52-4
UNSPSC
12352005
Hazard Statement
H302
Target
Autophagy; Parasite; Toll-like Receptor (TLR)
Type
Reference compound
Related Pathways
Anti-infection; Autophagy; Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/desethyl-chloroquine.html
Solubility
10 mM in DMSO
Smiles
CC(NC1=CC=NC2=CC(Cl)=CC=C12)CCCNCC
Molecular Formula
C16H22ClN3
Molecular Weight
291.82
Precautions
P264-P270-P330-P501
References & Citations
[1]Ajayi FO, et al. Comparison of the partitioning in vitro of chloroquine and its desethyl metabolites between the erythrocytes and plasma of healthy subjects and those with falciparum malaria. Afr J Med Med Sci. 1989 Jun;18 (2) :95-100.|[2]Vodicka P, et al. Assessment of chloroquine treatment for modulating autophagy flux in brain of WT and HD mice. J Huntingtons Dis. 2014;3 (2) :159-74.|[3]Said A, et al. Chloroquine promotes IL-17 production by CD4+ T cells via p38-dependent IL-23 release by monocyte-derived Langerhans-like cells. J Immunol. 2014 Dec 15;193 (12) :6135-43.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Plasmodium
Frequently Asked Questions
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