Cletoquine

Cletoquine (Desethylhydroxychloroquine) is a major active metabolite of Hydroxychloroquine. Cletoquine is produced in the liver by CYP2D6, CYP3A4, CYP3A5, and CYP2C8 isoenzymes. Cletoquine is also a Chloroquine derivative and has the ability to against the chikungunya virus (CHIKV) . Cletoquine has antimalarial effects and has the potential for autoimmune diseases treatment[1][2].

Product Specifications

CAS Number

[4298-15-1]

Product Name Alternative

Desethylhydroxychloroquine

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

CHIKV; Influenza Virus; Parasite

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-anti-virus

Field of Research

Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/cletoquine.html

Solubility

10 mM in DMSO

Smiles

CC(NC1=CC=NC2=CC(Cl)=CC=C12)CCCNCCO

Molecular Formula

C16H22ClN3O

Molecular Weight

307.82

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Kumar M, et al. Molecular docking studies of chloroquine and its derivatives against P23pro-zbd domain of chikungunya virus: Implication in designing of novel therapeutic strategies. J Cell Biochem. 2019 Oct;120 (10) :18298-18308.|[2]Charlier B, et al. Development of a novel ion-pairing HPLC-FL method for the separation and quantification of hydroxychloroquine and its metabolites in whole blood. Biomed Chromatogr. 2018 Aug;32 (8) :e4258.|[3]Chhonker YS, et al. Simultaneous quantitation of hydroxychloroquine and its metabolites in mouse blood and tissues using LC-ESI-MS/MS: An application for pharmacokinetic studies. J Chromatogr B Analyt Technol Biomed Life Sci. 2018 Jan 1;1072:320-327.