Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Duocarmycin DM

Duocarmycin DM, a DNA minor-groove alkylator, is an antibody agent conjugates (ADCs) toxin. Duocarmycin DM is based on its characteristic curved indole structure and a spirocyclopropylcyclohexadienone electrophile to act anticancer activity[1][2].

Product Specifications

UNSPSC

12352203

Target

ADC Payload; DNA Alkylator/Crosslinker

Type

ADC Related

Related Pathways

Antibody-drug Conjugate/ADC Related; Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/duocarmycin-dm.html

Purity

99.15

Solubility

10 mM in DMSO

Smiles

OC1=C2C(C=CC=C2)=C3C(N(C[C@H]3CCl)C(C4=CC5=C(N4)C=CC(OCCN(C)C)=C5)=O)=C1.OC(C(F)(F)F)=O

Molecular Formula

C28H27ClF3N3O5

Molecular Weight

577.98

References & Citations

[1]Patil PC, et al. A Short Review on the Synthetic Strategies of Duocarmycin Analogs that are Powerful DNA Alkylating Agents. Anticancer Agents Med Chem. 2015;15 (5) :616-630.|[2]Koch MF, et al. Structural, Biochemical, and Computational Studies Reveal the Mechanism of Selective Aldehyde Dehydrogenase 1A1 Inhibition by Cytotoxic Duocarmycin Analogues. Angew Chem Int Ed Engl. 2015 Nov 9;54 (46) :13550-4.|[3]Chen KC, et al. Selective cancer therapy by extracellular activation of a highly potent glycosidic duocarmycin analogue. Mol Pharm. 2013;10 (5) :1773-1782.|[4]Tietze LF, Krewer B, von Hof JM, Frauendorf H, Schuberth I. Determination of the biological activity and structure activity relationships of drugs based on the highly cytotoxic duocarmycins and CC-1065. Toxins (Basel) . 2009;1 (2) :134-150. |[5]Tietze LF, Schuster HJ, Schmuck K, Schuberth I, Alves F. Duocarmycin-based prodrugs for cancer prodrug monotherapy. Bioorg Med Chem. 2008;16 (12) :6312-6318.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C (Powder, sealed storage, away from moisture)

Scientific Category

ADC Related

Clinical Information

No Development Reported

Isoform

Daunorubicins/Doxorubicins

Available Sizes

Frequently Asked Questions

More Discoveries

Explore Other Products

Browse additional items from our catalog

GSTM5 (NM_000851) Human Over-expression Lysate
LC424493 20 µg

GSTM5 (NM_000851) Human Over-expression Lysate

Sign In for Pricing
View Details
Tissue FFPE Sections, Lung
CS701016 5x 5 µm

Tissue FFPE Sections, Lung

Sign In for Pricing
View Details
Frozen Tissue Sections, Stomach
CS627370 5x 5 µm

Frozen Tissue Sections, Stomach

Sign In for Pricing
View Details
COX7A1 Human Gene Knockout Kit (CRISPR)
KN401154 1 Kit

COX7A1 Human Gene Knockout Kit (CRISPR)

Sign In for Pricing
View Details
Cathepsin B Recombinant Rabbit Monoclonal Antibody [JA11-02]
ET1704-03 100 µL

Cathepsin B Recombinant Rabbit Monoclonal Antibody [JA11-02]

Sign In for Pricing
View Details
Fosetyl Aluminum-d15 (Technical Grade)
TRC-F727452-5MG 5 mg

Fosetyl Aluminum-d15 (Technical Grade)

Sign In for Pricing
View Details