DHODH-IN-15

DHODH-IN-15 (Compound 7b) is a hydroxyfurazan analog of A771726. DHODH-IN-15 is a dihydroorotate dehydrogenase (DHODH) inhibitor with an IC50 of 11 μM for rat liver DHODH. DHODH-IN-15 can be used for rheumatoid arthritis[1].

Product Specifications

CAS Number

[1364791-88-7]

UNSPSC

12352005

Target

Dihydroorotate Dehydrogenase; DNA/RNA Synthesis

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Metabolic Enzyme/Protease

Applications

COVID-19-anti-virus

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/dhodh-in-15.html

Solubility

10 mM in DMSO

Smiles

O=C(C1=NONC1=O)NC2=CC=C(C3=CC=CC=C3)C=C2

Molecular Formula

C15H11N3O3

Molecular Weight

281.27

References & Citations

[1]Lolli ML, et al. New inhibitors of dihydroorotate dehydrogenase (DHODH) based on the 4-hydroxy-1,2,5-oxadiazol-3-yl (hydroxyfurazanyl) scaffold. Eur J Med Chem. 2012 Mar;49:102-9.