HDHODH-IN-7
DHODH-IN-9 (Compound 10k) is an azine-bearing analogue and is a human dihydroorotate dehydrogenase inhibitor. DHODH-IN-9 has antiviral effect with a pMIC50 of 7.4[1].
Product Specifications
CAS Number
1644156-41-1
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
Dihydroorotate Dehydrogenase; DNA/RNA Synthesis; Influenza Virus
Type
Reference compound
Related Pathways
Anti-infection; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/dhodh-in-9.html
Solubility
10 mM in DMSO
Smiles
CC(C)OC1=NN(C2=NC=C(C3CC3)C=N2)C(C)=C1CC4=CC=CC=C4F
Molecular Formula
C21H23FN4O
Molecular Weight
366.43
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362-P403+P233-P405-P501
References & Citations
[1]Lucas-Hourani M, et al.Original 2- (3-Alkoxy-1H-pyrazol-1-yl) azines Inhibitors of Human Dihydroorotate Dehydrogenase (DHODH) .J Med Chem. 2015 Jul 23;58 (14) :5579-98.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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