HDHODH-IN-7

DHODH-IN-9 (Compound 10k) is an azine-bearing analogue and is a human dihydroorotate dehydrogenase inhibitor. DHODH-IN-9 has antiviral effect with a pMIC50 of 7.4[1].

Product Specifications

CAS Number

[1644156-41-1]

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Dihydroorotate Dehydrogenase; DNA/RNA Synthesis; Influenza Virus

Type

Reference compound

Related Pathways

Anti-infection; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/dhodh-in-9.html

Solubility

10 mM in DMSO

Smiles

CC(C)OC1=NN(C2=NC=C(C3CC3)C=N2)C(C)=C1CC4=CC=CC=C4F

Molecular Formula

C21H23FN4O

Molecular Weight

366.43

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362-P403+P233-P405-P501

References & Citations

[1]Lucas-Hourani M, et al.Original 2- (3-Alkoxy-1H-pyrazol-1-yl) azines Inhibitors of Human Dihydroorotate Dehydrogenase (DHODH) .J Med Chem. 2015 Jul 23;58 (14) :5579-98.