DHODH-IN-8

DHODH-IN-8 (Compound 27) is an inhibitor of human and Plasmodium falciparum dihydroorotate dehydrogenase (DHODH) with IC50s of 0.13 μM and 47.4 μM, and Kis of 0.016 μM and 5.6 μM, respectively. DHODH-IN-8 has antimalarial activity[1].

Product Specifications

CAS Number

[1148126-03-7]

UNSPSC

12352005

Hazard Statement

H302-H312-H315-H319-H332-H335

Target

Dihydroorotate Dehydrogenase; DNA/RNA Synthesis; Parasite

Type

Reference compound

Related Pathways

Anti-infection; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/dhodh-in-8.html

Solubility

10 mM in DMSO

Smiles

C/C(O)=C(C#N)/C(NC1=CC=C(C2=CC=CC=C2Cl)C=C1)=O

Molecular Formula

C17H13ClN2O2

Molecular Weight

312.75

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362-P403+P233-P405-P501

References & Citations

[1]Davies M, et al. Structure-based design, synthesis, and characterization of inhibitors of human and Plasmodium falciparum dihydroorotate dehydrogenases. J Med Chem. 2009 May 14;52 (9) :2683-93.