HDHODH-IN-5
DHODH-IN-7 is a human dihydroorotate dehydrogenase (DHODH) inhibitor, with an IC50 of 0.91 μM. DHODH-IN-7 induces differentiation in acute myeloid leukemia[1].
Product Specifications
CAS Number
2029049-77-0
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Dihydroorotate Dehydrogenase; DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/dhodh-in-7.html
Purity
98.55
Solubility
10 mM in DMSO
Smiles
O=C(NCCC(N[C@@H]1CCCC2=C1C=CC=C2)=O)C3=CC=C(C(F)(F)F)C=C3
Molecular Formula
C21H21F3N2O2
Molecular Weight
390.40
Precautions
H302, H315, H319, H335
References & Citations
[1]Lewis TA, et al. Development of ML390: A Human DHODH Inhibitor That Induces Differentiation in Acute Myeloid Leukemia. ACS Med Chem Lett. 2016 Sep 28;7 (12) :1112-1117.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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