Becatecarin
Product Specifications
UNSPSC Description
Becatecarin is a rebeccamycin analog with antitumor effects. Becatecarin intercalates into DNA and inhibites the catalytic activity of topoisomerases I/II.
Target Antigen
Topoisomerase
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/becatecarin.html
Solubility
10 mM in DMSO
Smiles
ClC1=CC=CC2=C1NC3=C2C4=C(C(N(CCN(CC)CC)C4=O)=O)C5=C3N([C@@H]6O[C@H](CO)[C@@H](OC)[C@H](O)[C@H]6O)C7=C(Cl)C=CC=C75
Molecular Weight
669.55
References & Citations
[1]Long BH, Rose WC, Vyas DM, Matson JA, Forenza S. Discovery of antitumor indolocarbazoles: rebeccamycin, NSC 655649, and fluoroindolocarbazoles. Curr Med Chem Anticancer Agents. 2002;2(2):255-266. |[2]Robey RW, Obrzut T, Shukla S, et al. Becatecarin (rebeccamycin analog, NSC 655649) is a transport substrate and induces expression of the ATP-binding cassette transporter, ABCG2, in lung carcinoma cells. Cancer Chemother Pharmacol. 2009;64(3):575-583.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-13565/Becatecarin-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-13565/
Clinical Information
Phase 3
CAS Number
119673-08-4
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