DHODH-IN-4

DHODH-IN-4 (compound 17) is a human and Plasmodium falciparum dihydroorotate dehydrogenase (DHODH) inhibitor, with IC50 values of 4 μM and 0.18 μM for PfDHODH and HsDHODH, respectively. DHODH-IN-4 (compound 17) possess antimalarial activity[1].

Product Specifications

CAS Number

[1148125-93-2]

UNSPSC

12352005

Target

Dihydroorotate Dehydrogenase; DNA/RNA Synthesis; Parasite

Type

Reference compound

Related Pathways

Anti-infection; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease

Applications

COVID-19-anti-virus

Field of Research

Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/dhodh-in-4.html

Solubility

10 mM in DMSO

Smiles

C/C(O)=C(C#N)/C(NC1=CC=C(C2=CC=CC=C2Cl)C=C1Cl)=O

Molecular Formula

C17H12Cl2N2O2

Molecular Weight

347.20

References & Citations

[1]Davies M, et al. Structure-based design, synthesis, and characterization of inhibitors of human and Plasmodium falciparum dihydroorotate dehydrogenases. J Med Chem. 2009 May 14;52 (9) :2683-93.